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SYNTHESIS AND ANTIMICROBAIAL EVALUTION OF 3-ISOBUTYL-2,6-DI(THIOPHENYL-3) PIPERIDIN-4-ONE DERIVATIVES

Pages: 42 to 47

Kholoud Fahed Hamak, F.Kandil, S.Hamo

Abstract:

In a wide program of extensive search¬† for new and¬† efficient antimicrobial agents,3-isobutyl -2,6-di(thiophenyl-3)piperidin-4-one(1) and its derivatives (2-4) were synthesized and characterized by IR,LC-MS,1H-NMR,13C-NMR.The synthesized compounds 1-5 were tested for their antibacterial activity in vitro against streptococcus, bacillus subtilis, Esherichia coli, pseudomonas, and Klebsiella peumoniae. as the standard drug” streptomycin” was used.

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