Ganesamoorthy Thirunarayanan and Krishnamoorthy Guna Sekar
Some 4-(6- methyl-2- naphthyl)-5,6- dihydro-6- (substituted phenyl)-4H- 1,3-oxazine-2- amines have been synthesised by hydroxyapatite catalyzed solvent-free cyclization of 6-methyl- 2-naphthyl chalcones and urea under microwave irradiation. The yields of the oxazine were more than 85%. The synthesised oxazine amines have been characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of all prepared 4-(6- methyl-2- naphthyl)-5, 6-dihydro- 6-(substituted phenyl)-4H- 1,3-oxazine-2- amines have been evaluated using Bauer-Kirby disc diffusion method with a variety of bacterial and fungal strains.