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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF NEW BRIDGED AND MACROCYCLIC SCHIFF BASES

Pages: 77 to 87

Ahmad Falah

Abstract:

In this work we focused on the synthesis of new Open Schiff bases were prepared by condensation of salicylaldehyde with both  4,4′-diaminodiphenyl methane,4,4′-diamino diphenyl sulphide,and condensation of O-vanilin with diethyl ester of terephthalic acid respectively, and also were prepared New Macrocyclic Schiff Bases by condensation of 1,6-dibromohexane with thiocarbohydrazid. The Schiff base were checked by different spectral techniques (LC-MS, 1H-NMR, IR).The Schiff bases have been screened for their antibacterial activity, where compound (II) showed promising results against gram positive and gram negative bacteria.

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